Cytogenetic findings in 33 osteosarcomas
Author
Summary, in English
Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms 1p, 1q, 3p, 3q, 7q, 11p, 17p and 22q. Chromosome bands 1q11, 1q21, 1q42 and 7q11 were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the sole change, were found in all 3 parosteal OS, which is in agreement with the findings in 1 previously reported parosteal OS. The association between ring formation and parosteal morphology represents the first cytogenetic-morphologic entity among OS.
Department/s
Publishing year
1993-08-19
Language
English
Pages
44-50
Publication/Series
International Journal of Cancer
Volume
55
Issue
1
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Cancer and Oncology
- Medical Genetics
Keywords
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Bone Neoplasms
- Child
- Child, Preschool
- Chromosome Aberrations
- DNA, Neoplasm
- Female
- Flow Cytometry
- Humans
- Karyotyping
- Male
- Middle Aged
- Osteosarcoma
- Ploidies
- Ring Chromosomes
- Journal Article
- Research Support, Non-U.S. Gov't
Status
Published
Research group
- Orthopaedic Sarcoma Research
- Late effects after childhood cancer treatment
ISBN/ISSN/Other
- ISSN: 0020-7136