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Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

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Author

  • Marc Tjwa
  • Lola Bell Ido-Martin
  • Yuan Lin
  • Esther Lutgens
  • Stephane Plaisance
  • Francoise Bono
  • Nathalie Delesque-Touchard
  • Caroline Herve
  • Rute Moura
  • An D Billiau
  • Cristina Aparicio
  • Marcel Levi
  • Mat Daemen
  • Mieke Dewerchin
  • Florea Lupu
  • Jef Arnout
  • Jean-Marc Herbert
  • Mark Waer
  • Pablo Garcia de Frutos
  • Björn Dahlbäck
  • Peter Carmeliet
  • Marc F Hoylaerts
  • Lieve Moons
Show all

Summary, in English

The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

Publishing year

2008

Language

English

Pages

4096-4105

Publication/Series

Blood

Volume

111

Issue

8

Document type

Journal article

Publisher

American Society of Hematology

Topic

  • Hematology

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1528-0020