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ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus.

På svenska

Author

  • Max Levin
  • Seth Goldbarg
  • Anders Lindqvist
  • Karl Swärd
  • Christine Roman
  • Bao Mei Liu
  • Lillemor Mattsson Hultén
  • Jan Borén
  • Ronald I Clyman

Summary, in English

Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure.

Department/s

Publishing year

2005

Language

English

Pages

801-805

Publication/Series

Pediatric Research

Volume

57

Issue

6

Document type

Journal article

Publisher

International Pediatric Foundation Inc.

Topic

  • Pediatrics

Status

Published

Research group

  • Islet cell physiology
  • Vascular Physiology
  • Cellular Biomechanics

ISBN/ISSN/Other

  • ISSN: 1530-0447