A multisubstrate deoxyribonucleoside kinase from plants.
Author
Summary, in English
Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
Department/s
Publishing year
2008
Language
English
Pages
489-490
Publication/Series
Nucleic acids symposium series
Issue
52
Document type
Journal article
Publisher
Oxford University Press
Topic
- Biological Sciences
Status
Published
ISBN/ISSN/Other
- ISSN: 0261-3166