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Lentiviral Vectors for Use in the Central Nervous System.

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Author

Summary, in English

Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system throughout the past decade since they transduce most cell types in the brain, resulting in high-level and long-term transgene expression. This review discusses some of the recent progress in this field, including preclinical gene therapy experiments in disease models, development of regulated vectors, and the application of siRNA's using lentiviral vectors. We also describe some of the features that make lentiviral vectors a likely candidate for human gene therapy in the brain.

Department/s

Publishing year

2006

Language

English

Pages

484-493

Publication/Series

Molecular Therapy

Volume

13

Issue

3

Document type

Journal article review

Publisher

Nature Publishing Group

Topic

  • Medical Genetics

Keywords

  • neurological disorders
  • brain
  • lentivirus
  • gene therapy
  • siRNA
  • Tet system

Status

Published

Research group

  • CNS Gene Therapy

ISBN/ISSN/Other

  • ISSN: 1525-0024