Serological assessment for celiac disease in IgA deficient adults.

Summary, in English

Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to investigate the prevalence of these markers in a large cohort of IgA deficient adults with confirmed or suspected CD and relate the findings to gluten free diet.

• Author: Ning Wang; Lennart Truedsson; Kerstin Elvin; Bengt A Andersson; Johan Rönnelid; Lucia Mincheva-Nilsson; Annica Lindkvist; Jonas F Ludvigsson; Lennart Hammarström; Charlotte Dahle
• Department/s: Division of Microbiology, Immunology and Glycobiology - MIG
• Publishing year: 2014
• Language: English
• Publication/Series: PLoS ONE
• Volume: 9
• Issue: 4
• Full text: - 487 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24709954?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0093180
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Microbiology in the medical area; Immunology in the medical area
• Status: Published
• ISBN/ISSN/Other: ISSN: 1932-6203