Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?
Author
Summary, in English
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease.
Department/s
Publishing year
2016
Language
English
Pages
57-63
Publication/Series
Journal of Parkinson's Disease
Volume
6
Issue
1
Document type
Journal article
Publisher
IOS Press
Topic
- Cell and Molecular Biology
Status
Published
ISBN/ISSN/Other
- ISSN: 1877-718X