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Poor Reproducibility of Allergic Rhinitis SNP Associations

På svenska

Author

  • Daniel Nilsson
  • Anand Kumar Andiappan
  • Christer Hallden
  • Chew Fook Tim
  • Torbjörn Säll
  • De Yun Wang
  • Lars-Olaf Cardell

Summary, in English

Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.

Department/s

Publishing year

2013

Language

English

Publication/Series

PLoS ONE

Volume

8

Issue

1

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Biological Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 1932-6203