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Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100(R).

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Author

  • Christina Silver
  • Hanna Lindgren
  • Ronald Pero
  • Tomas Leanderson
  • Fredrik Ivars

Summary, in English

We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA inhibited NF-κB activity in exposed cells at similar concentrations. Thus, our present data identify QA as a candidate component for both in vivo and in vitro biological effects of the C-Med 100® extract

Department/s

Publishing year

2005

Language

English

Pages

219-229

Publication/Series

International Immunopharmacology

Volume

5

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Pharmacology and Toxicology

Keywords

  • Proliferation
  • Uncaria tomentosa
  • Inhibition
  • NF-κB
  • Cell survival

Status

Published

Research group

  • Diabetes - Immunovirology
  • Immunology

ISBN/ISSN/Other

  • ISSN: 1878-1705