Infiltration of Mast Cells in Rat Colon Is a Consequence of Ischemia/Reperfusion.
Author
Summary, in English
Intestinal ischemia as well as mastocytosis occur in patients with inflammatory bowel disease and irritable bowel syndrome. Our aim was to clarify how ischemia with reperfusion (I/R) affects the structure, enteric neurons, and immune cells in the colon. Rats were subjected to colon ischemia for 1 h and reperfused for 1 day up to 20 weeks; sham-operated rats were used as controls. No structural remodeling of the intestinal segment was detected after I/R. The number and distribution of eosinophils were not affected by I/R. Local areas containing numerous mast cells were detected in the muscle layers, the serosa, and in and around the myenteric ganglia 4-20 weeks post ischemia. It was notable that myenteric ganglionic formations within mast-cell-rich areas virtually lacked neurons. Mast cells were rarely found in controls. In conclusion, I/R of the colon attracts mast cells, and death of myenteric neurons occurs in such locations.
Department/s
- Neurogastroenterology
Publishing year
2008
Language
English
Pages
3158-3169
Publication/Series
Digestive Diseases and Sciences
Volume
53
Links
Document type
Journal article
Publisher
Springer
Topic
- Gastroenterology and Hepatology
Status
Published
Research group
- Neurogastroenterology
ISBN/ISSN/Other
- ISSN: 1573-2568