Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
Author
Summary, in English
Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Department/s
- Division of Clinical Genetics
- Clinical Microbiology, Malmö
- Neurosurgery
- Internal Medicine - Epidemiology
- Paediatrics (Lund)
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2013
Language
English
Pages
91-93
Publication/Series
Pediatric Blood & Cancer
Volume
60
Issue
9
Links
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Pediatrics
Status
Published
Research group
- Clinical Microbiology, Malmö
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 1545-5017