Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Summary, in English

Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.

• Author: Pontus Dunér; Isabel Goncalves; Helena Grufman; Andreas Edsfeldt; Fong To; Mihaela Nitulescu; Jan Nilsson; Eva Bengtsson
• Department/s: EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Translational Studies
• Publishing year: 2015
• Language: English
• Pages: 26-32
• Publication/Series: Atherosclerosis
• Volume: 240
• Issue: 1
• Full text: - 1 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25746374?dopt=Abstract; http://dx.doi.org/10.1016/j.atherosclerosis.2015.02.043
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Translational Studies
• ISBN/ISSN/Other: ISSN: 1879-1484