Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

Summary, in English

Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. (C) 2011 Movement Disorder Society

• Author: Marios Politis; Wolfgang H. Oertel; Kit Wu; Niall P. Quinn; Oliver Pogarell; David J. Brooks; Anders Björklund; Olle Lindvall; Paola Piccini
• Department/s: Neurobiology; Neurogenesis and cell therapy; Neurology, Lund; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2011
• Language: English
• Pages: 1997-2003
• Publication/Series: Movement Disorders
• Volume: 26
• Issue: 11
• Links: http://dx.doi.org/10.1002/mds.23743
• Document type: Journal article
• Publisher: John Wiley & Sons Inc.
• Topic: Neurology
• Keywords: Parkinson; transplantation; dyskinesias; serotonin transporter; dopamine transporter
• Status: Published
• Research group: Neurobiology; Neurogenesis and cell therapy
• ISBN/ISSN/Other: ISSN: 0885-3185