Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C.

Summary, in English

Platelets are the main source of microparticles in plasma and the concentration of microparticles is increased in many diseases. As microparticles expose negatively charged phospholipids, they can bind and assemble the procoagulant enzyme-cofactor complexes. Our aim was to elucidate possible regulation of these complexes on microparticles by the anticoagulant protein C system.

• Author: Sofia Somajo; Ruzica Livaja Koshiar; Eva Norström; Björn Dahlbäck
• Department/s: Clinical Chemistry, Malmö
• Publishing year: 2014
• Language: English
• Pages: 144-152
• Publication/Series: Thrombosis Research
• Volume: 134
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24835672?dopt=Abstract; http://dx.doi.org/10.1016/j.thromres.2014.04.031
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1879-2472