Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease.
Author
Summary, in English
Background/objectives: to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes.Design: a cross-sectional analysis of a healthy subset from the Good Aging in Skåne-cohort study representative of the Swedish general population.Subjects: 1252 participants without vascular disease and diabetes (43.9% men) of whom 203 were over 80 years old were included from the original cohort of 2931.Methods: plasma cystatin C and plasma creatinine were used as markers for GFR. Estimated GFR (eGFR) was calculated with three chronic kidney disease epidemiology collaboration (CKD-EPI) formulas involving cystatin C, creatinine or both.Results: the median for plasma cystatin C was 0.93 mg/l (60-69 years old), 1.04 (70-79 years old) and 1.24 (80+ years old). The difference in mg/l between the 5th and 95th percentile was 0.46, 0.62 and 0.90 for these age groups. Male sex increased the age effect on plasma cystatin C levels with 0.004 mg/l/year (P = 0.03), adjusted for vascular risk factors. Smoking, lower HDL and higher diastolic blood pressure were associated with higher cystatin C levels. 54.7% (CKD-EPI creatinine) to 73.9% (CKD-EPI cystatin C) of the 80+ had an eGFR < 60 ml/min/1.73 m(2).Conclusion: non-diabetics without overt vascular disease exhibit an age related but heterogeneous decline in renal function. The ageing effect is more pronounced in men. At least half of healthy 80+ years old could be expected to have at least CKD Stage 3 with eGFR < 60 ml/min/1.73 m(2).
Department/s
- Geriatric Medicine
- Internal Medicine - Epidemiology
- EpiHealth: Epidemiology for Health
Publishing year
2014
Language
English
Pages
411-417
Publication/Series
Age and Ageing
Volume
43
Issue
3
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Document type
Journal article
Publisher
Oxford University Press
Topic
- Gerontology, specializing in Medical and Health Sciences
Status
Published
Research group
- Geriatric Medicine
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 1468-2834