Factors associated with early mortality in HIV-positive men and women investigated for tuberculosis at Ethiopian health centers
Author
Summary, in English
Despite increasing access to antiretroviral treatment (ART) in low-income countries, HIV-related mortality is high, especially in the first months following ART initiation. We aimed to evaluate the impact of TB coinfection on early mortality and to assess gender-specific predictors of mortality in a cohort of Ethiopian adults subjected to intensified casefinding for active TB before starting ART. Material and Methods: Prospectively recruited ART-eligible adults (n = 812, 58.6% female) at five Ethiopian health centers were followed for 6 months. At inclusion sputum culture, Xpert MTB/RIF, and smear microscopy were performed (158/812 [19.5%] had TB). Primary outcome was all-cause mortality. We used multivariate Cox models to identify predictors of mortality. Results: In total, 37/812 (4.6%) participants died, 12 (32.4%) of whom had TB. Karnofsky performance score (KPS) and mid-upper arm circumference (MUAC) were associated with mortality in the whole population. However, the associations were different in men and women. In men, only MUAC remained associated with mortality (adjusted hazard ratio [aHR] 0.71 [95% CI 0.57-0.88]). In women, KPS
Department/s
- Infectious Diseases Research Unit
- Medical Microbiology, Malmö
Publishing year
2016-06-01
Language
English
Publication/Series
PLoS ONE
Volume
11
Issue
6
Document type
Journal article
Publisher
Public Library of Science (PLoS)
Topic
- Infectious Medicine
Status
Published
Research group
- Infectious Diseases Research Unit
- Medical Microbiology, Malmö
ISBN/ISSN/Other
- ISSN: 1932-6203