Global transcriptional changes following statin treatment in breast cancer.

Summary, in English

Statins purportedly exert anti-tumoral effects, but the underlying mechanisms are currently not fully elucidated. The aim of this study was to explore potential statin-induced effects on global gene expression profiles in primary breast cancer.

• Author: Olöf Bjarnadottir; Siker Kimbung; Ida Johansson; Srinivas Veerla; Mats Jönsson; Pär-Ola Bendahl; Dorthe Grabau; Ingrid Hedenfalk; Signe Borgquist
• Department/s: Breast cancer prevention & intervention; Breastcancer-genetics; Tumor microenvironment; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Pages: 3402-3411
• Publication/Series: Clinical Cancer Research
• Volume: 21
• Issue: 15
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25840970?dopt=Abstract; http://dx.doi.org/10.1158/1078-0432.CCR-14-1403
• Document type: Journal article
• Publisher: American Association for Cancer Research
• Topic: Cancer and Oncology
• Status: Published
• Research group: Breast cancer prevention & intervention
• ISBN/ISSN/Other: ISSN: 1078-0432