Influence of dexamethasone and alpha-ketoglutarate on growth and development of the skeletal system of pigs
Author
Summary, in English
The aim of the study was to establish the influence of dexamethasone and/or alpha-ketoglutarate (AKG) on the growth, mineralization, geometric and mechanical properties of ribs as a methodological model. The experiment was conducted during the final 24 days of prenatal life and first 14 days of neonatal life. The volumetric bone density of the trabecular and cortical bone was determined separately using the quantitative computed tomography (QCT) method and Somatom AR. T - Siemens apparatus. The mechanical properties were determined using the three-point bending test according to the method by Ferretti et al. The obtained results indicate that maternal administration of dexamethasone increased volumetric mineral density, although the mechanical parameters had lower values. Prenatal administration of AKG decreased all the geometric and mechanical parameters of the investigated ribs. The results obtained during the administration of the compound in neonatal life were the opposite of the prenatal results. Dexamethasone and AKG given together had the same influence on mineralization and other properties AND increasing their values during prenatal and neonatal life. This model of administrating dexamethasone and AKG maternally during prenatal life with the intention of provoking structural growth of the skeleton may be useful in further elucidating some biological and pharmacological factors on bone formation in prenatal life.
Department/s
Publishing year
2005
Language
Polish
Pages
526-531
Publication/Series
Medycyna Weterynaryjna
Volume
61
Issue
5
Document type
Journal article
Publisher
POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE
Topic
- Zoology
Keywords
- dexamethasone
- AKG
- ribs
- prenatal life
- piglets
Status
Published
ISBN/ISSN/Other
- ISSN: 0025-8628