Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.
Author
Summary, in English
The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.
Publishing year
2014
Language
English
Pages
288-296
Publication/Series
Cardiovascular Research
Volume
101
Issue
2
Full text
Links
Document type
Journal article
Publisher
Oxford University Press
Topic
- Cardiac and Cardiovascular Systems
Status
Published
Research group
- Vascular Physiology
- Cellular Biomechanics
- Molecular Vascular Physiology
ISBN/ISSN/Other
- ISSN: 1755-3245