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Supported liquid membrane extraction of urinary trans, trans-muconic acid, a biomarker for benzene exposure

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Author

Summary, in English

In this study, sample preparation of urinary trans, trans-muconic acid (tt-MA), a minor metabolite and biomarker of benzene, by means of Supported Liquid Membrane (SLM) extraction has been investigated. The sample extract was automatically transferred on-line to an ion exchange chromatographic column and the analytes were detected using a photodiode array detector. Automation of the system was accomplished using a robotic sample preparation processor integrated into the chromatographic system. Detection limits calculated from the baseline noise was in the sub-ppb range, and quantification of tt-MA is safe down to 10 ppb.

Publishing year

2002

Language

English

Pages

351-355

Publication/Series

Journal of Separation Science

Volume

25

Issue

5-6

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Analytical Chemistry

Keywords

  • extraction
  • supported liquid membrane
  • benzene exposure
  • biomarker
  • muconic acid
  • urine analysis

Status

Published

ISBN/ISSN/Other

  • ISSN: 1615-9314