Stem Cell States, Fates, and the Rules of Attraction
Author
Summary, in English
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. The nature of the stem cell substates and their relationship to commitment to differentiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors.
Publishing year
2009
Language
English
Pages
387-397
Publication/Series
Cell Stem Cell
Volume
4
Issue
5
Document type
Journal article review
Publisher
Cell Press
Topic
- Cell Biology
Status
Published
ISBN/ISSN/Other
- ISSN: 1934-5909