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Number of spikes in climbing fibers determines the direction of cerebellar learning.

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Author

Summary, in English

Cerebellar learning requires context information from mossy fibers and a teaching signal through the climbing fibers from the inferior olive. Although the inferior olive fires in bursts, virtually all studies have used a teaching signal consisting of a single pulse. Following a number of failed attempts to induce cerebellar learning in decerebrate ferrets with a nonburst signal, we tested the effect of varying the number of pulses in the climbing fiber teaching signal. The results show that training with a single pulse in a conditioning paradigm in vivo does not result in learning, but rather causes extinction of a previously learned response.

Publishing year

2013

Language

English

Pages

13436-13440

Publication/Series

Journal of Neuroscience

Volume

33

Issue

33

Document type

Journal article

Publisher

Society for Neuroscience

Topic

  • Neurosciences

Status

Published

Project

  • Thinking in Time: Cognition, Communication and Learning

Research group

  • Associative Learning

ISBN/ISSN/Other

  • ISSN: 1529-2401