A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
Author
Summary, in English
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.
Department/s
Publishing year
2010
Language
English
Pages
232-241
Publication/Series
Journal of Controlled Release
Volume
147
Document type
Journal article
Publisher
Elsevier
Topic
- Chemical Engineering
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-4995