Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Summary, in English

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

• Author: Ola Bergendorff; Kim Dekermendjian; Mogens Nielsen; Rudong Shan; Robin Witt; Jinglu Ai; Olov Sterner
• Department/s: Dermatology and Venereology (Lund); Centre for Analysis and Synthesis
• Publishing year: 1997
• Language: English
• Pages: 1121-1124
• Publication/Series: Phytochemistry
• Volume: 44
• Issue: 6
• Links: http://dx.doi.org/10.1016/S0031-9422(96)00703-0
• Document type: Journal article
• Publisher: Elsevier
• Topic: Dermatology and Venereal Diseases
• Status: Published
• ISBN/ISSN/Other: ISSN: 0031-9422