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Isolation and characterization of two verrucarins from Myrothecium roridum

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Author

Summary, in English

In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.

Publishing year

2006

Language

English

Pages

309-314

Publication/Series

Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences

Volume

61

Issue

5-6

Document type

Journal article

Publisher

Verlag der Zeitschrift für Naturforschung

Topic

  • Organic Chemistry

Keywords

  • Myrothecium roridum
  • 16-hydroxyverrucarin A
  • verrucarin X
  • protein
  • synthesis inhibitors

Status

Published

ISBN/ISSN/Other

  • ISSN: 0939-5075