Genotyping of human papillomavirus in triaging of low-grade cervical cytology.

Summary, in English

OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated. RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse. CONCLUSION: Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.

• Author: Anna Söderlund Strand; Carina Eklund; Levent Kemetli; Lena Grillner; Sven Törnberg; Joakim Dillner; Lena Dillner
• Department/s: Clinical Microbiology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2011
• Language: English
• Pages: 1-145
• Publication/Series: American Journal of Obstetrics and Gynecology
• Volume: 205
• Issue: 2
• Full text: - 58 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21658668?dopt=Abstract; http://dx.doi.org/10.1016/j.ajog.2011.03.056
• Document type: Journal article
• Publisher: Elsevier
• Topic: Obstetrics, Gynecology and Reproductive Medicine
• Status: Published
• Research group: Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1097-6868