Cyclometallated gold(iii) aryl-pyridine complexes as efficient catalysts for three-component synthesis of substituted oxazoles.

Summary, in English

Cyclometallated aryl-pyridine gold(iii) complexes are shown to be efficient catalysts for the multicomponent reaction between N-benzyl imines, alkynes, and acyl chlorides to form trisubstituted oxazoles. The reaction typically proceeds in good yields (up to over 80%) and short reaction times (∼15 minutes). The high stability of the investigated cyclometallated catalysts enables a retained efficiency for this reaction in terms of rate and yield using as little as 0.5 mol% catalyst, a reduction by an order of magnitude compared to previously used Au(iii)-salen complexes. An attractive feature of the present catalytic system is that active catalysts can be formed from simple pre-catalysts under the reaction conditions. Both cyclometallated and non-cyclometallated complexes were characterized in the solid state by single crystal X-ray diffraction.

• Author: Henrik von Wachenfeldt; Alexey Polukeev; Nagarajan Loganathan; Filip Paulsen; Philipp Röse; Marion Garreau; Ola Wendt; Daniel Strand
• Department/s: Centre for Analysis and Synthesis; Department of Chemistry
• Publishing year: 2015
• Language: English
• Pages: 5347-5353
• Publication/Series: Dalton Transactions
• Volume: 44
• Issue: 12
• Links: http://dx.doi.org/10.1039/c4dt03806a
• Document type: Journal article
• Publisher: Royal Society of Chemistry
• Topic: Chemical Sciences
• Status: Published
• ISBN/ISSN/Other: ISSN: 1477-9234