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Bioactive alkenylphenols from Piper obliquum.

På svenska

Author

  • Carola Valdivia
  • Nieves Marquez
  • John Eriksson
  • Antonio Vilaseca
  • Eduardo Muñoz
  • Olov Sterner

Summary, in English

Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

Publishing year

2008

Language

English

Pages

4120-4126

Publication/Series

Bioorganic & Medicinal Chemistry

Volume

16

Issue

7

Document type

Journal article

Publisher

Elsevier

Topic

  • Organic Chemistry
  • Industrial Biotechnology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0968-0896