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Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization

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Author

Summary, in English

Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human kidney. The present study helps to elucidate the pathophysiological functions of apoM in vivo.

Publishing year

2003

Language

English

Pages

67-72

Publication/Series

Acta Histochemica

Volume

105

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Biochemistry and Molecular Biology

Keywords

  • in situ hybridization
  • kidney
  • liver
  • apolipoprotein M

Status

Published

ISBN/ISSN/Other

  • ISSN: 0065-1281