Extraction of mercaptobenzothiazole compounds from rubber products
Author
Summary, in English
At evaluation of contact dermatitis caused by solid material, patch testing is usually performed with the material as such and with extracts of it. In this study, optimization of the extraction technique monitored by quantitative HPLC analysis of the extracted haptens is described for mercaptobenzothiazole derivatives. Several solvents with different properties are included. Acetone has traditionally been a solvent widely used for the extraction of organic haptens from solid products. However, acetone and other ketones are not inert solvents. The rubber accelerators 2-(4-morpholinyl mercapto) benzothiazole (MMBT) and N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) react with acetone, yielding 2 new compounds, which were isolated and characterised by NMR and MS. For the extraction of solid rubber products, methyl tert-butyl ether (MTBE) was found to be a more suitable solvent which is unreactive to most common haptens.
Publishing year
1997
Language
English
Pages
195-200
Publication/Series
Contact Dermatitis
Volume
36
Issue
4
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Dermatology and Venereal Diseases
Keywords
- hapten
- extraction
- patch testing technique
- rubber
- mercaptobenzothiazole
- allergic contact dermatitis
- acetone
- tetrahydrofuran
- methyl tert-butyl ether
Status
Published
ISBN/ISSN/Other
- ISSN: 0105-1873