Plasma-derived proteins in airway defence, disease and repair of epithelial injury
Author
Summary, in English
One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with rapidly emerging information (not detailed herein) on receptors, target cells and cellular responses to the plasma-derived molecules, must be considered in any realistic model that investigates "immuno-inflammatory" mechanisms of the airway mucosa.
Department/s
Publishing year
1998
Language
English
Pages
958-970
Publication/Series
European Respiratory Journal
Volume
11
Issue
4
Document type
Journal article
Publisher
European Respiratory Society
Topic
- Respiratory Medicine and Allergy
Keywords
- plasma proteins
- Mucosal biology in vivo
- plasma exudation
Status
Published
Research group
- Airway Inflammation and Immunology
ISBN/ISSN/Other
- ISSN: 1399-3003