Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells.

Summary, in English

The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cells undergoing acoustophoresis may impact cell viability, proliferation or cell function via subtle phenotypic changes. If this were the case, it would suggest that the acoustophoresis method would be a less useful tool for many cell analysis applications as well as for cell therapy.

• Author: Miguel Burguillos Garcia; Cecilia Magnusson; Maria Nordin; Andreas Lenshof; Per Augustsson; Magnus Hansson; Eskil Elmer; Hans Lilja; Patrik Brundin; Thomas Laurell; Tomas Deierborg
• Department/s: Department of Experimental Medical Science; Basal Ganglia Pathophysiology; Clinical Chemistry, Malmö; Department of Biomedical Engineering; Clinical Physiology (Lund); Clinical Neurophysiology; Neuroinflammation; EpiHealth: Epidemiology for Health; MultiPark: Multidisciplinary research focused on Parkinson´s disease; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2013
• Language: English
• Publication/Series: PLoS ONE
• Volume: 8
• Issue: 5
• Full text: - 1 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23724038?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0064233
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Medical Engineering
• Status: Published
• Research group: Basal Ganglia Pathophysiology; Clinical Chemistry, Malmö; Neuroinflammation
• ISBN/ISSN/Other: ISSN: 1932-6203