Biomarkers of early chronic obstructive pulmonary disease (COPD) in smokers and former smokers. Protocol of a longitudinal study.

Summary, in English

Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD: in fact, most develop some amount of pulmonary impairment. Smoking-related COPD is associated with both acute exacerbations and is closely correlated to comorbidities, such as cardiovascular disease and lung cancer. The objective of our study (KOL-Örestad) is to identify biomarkers in smokers and ex-smokers, with early signs of COPD, and compare these biomarkers with those of non-smokers and healthy smokers/ex-smokers. The participants in the study are recruited from Örestadskliniken, a primary health care clinic in Malmö, Sweden.

• Author: Mikael Truedsson; Johan Malm; Barbara Sahlin; May Bugge; Elisabet Wieslander; Magnus Dahlbäck; Roger Appelqvist; Thomas Fehniger; György Marko-Varga
• Department/s: Department of Translational Medicine; Clinical Chemistry, Malmö; Rehabilitation medicine; Department of Clinical Sciences, Lund; Tumor microenvironment; Department of Biomedical Engineering
• Publishing year: 2016
• Language: English
• Publication/Series: Clinical and Translational Medicine
• Volume: 5
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26951192?dopt=Abstract; http://dx.doi.org/10.1186/s40169-016-0086-5
• Document type: Journal article
• Publisher: Wiley
• Topic: Respiratory Medicine and Allergy; Biomaterials Science
• Status: Published
• Research group: Clinical Chemistry, Malmö; Rehabilitation medicine
• ISBN/ISSN/Other: ISSN: 2001-1326