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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

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Author

  • Sonia George
  • Annica Rönnbäck
  • Gunnar Gouras
  • Géraldine Petit
  • Fiona Grueninger
  • Bengt Winblad
  • Caroline Graff
  • Patrik Brundin

Summary, in English

The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.

Publishing year

2014

Language

English

Publication/Series

Acta Neuropathologica Communications

Volume

2

Issue

1

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Neurosciences

Status

Published

Research group

  • Experimental Dementia Research

ISBN/ISSN/Other

  • ISSN: 2051-5960