Quantitative and Qualitative Assessment of the Myocardium at Risk
Author
Summary, in English
Study I demonstrated, for the first time in humans, that there was a good correlation between the myocardium at risk assessed by T2-weighted CMR, which shows myocardial edema, and the myocardium at risk assessed by myocardial perfusion SPECT. Furthermore, the study also showed that T2-weighted CMR can be used up to 1 week after reperfusion therapy, allowing assessment of both myocardium at risk and infarct size to determine myocardial salvage in a single imaging session, without interfering with patient care.
Study II showed a significant difference between the myocardium at risk assessed by T2-weighted CMR and the endocardial extent of infarction measured by late gadolinium enhancement. Thus, endocardial extent of infarction can not be used to determine myocardium at risk, especially in patients with early reperfusion therapy with little or no infarction.
Study III demonstrated a good correlation between the myocardium at risk assessed by T2-weighted CMR and the myocardium at risk assessed by cine imaging early after injection of a gadolinium-based contrast agent, in patients 1 week after acute coronary occlusion. Thus, both methods can be used simultaneously or separately to determine MaR and subsequently myocardial salvage in a single imaging session.
Finally, Study IV showed that T2-weighted CMR can be used to determine the myocardium at risk in an ex vivo experimental model, both with and without the presence of gadolinium.
Department/s
Publishing year
2011
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2011:71
Full text
Document type
Dissertation
Publisher
Department of Clinical Physiology, Lund University
Topic
- Respiratory Medicine and Allergy
- Cardiac and Cardiovascular Systems
Keywords
- Acute myocardial infarction
- Myocardium at Risk
- magnetic resonance imaging
- T2-weighted imaging
- Myocardial perfusion SPECT
Status
Published
Supervisor
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-86871-21-5
Defence date
2 September 2011
Defence time
09:00
Defence place
Förekäsningssal 3, Skåne University Hospital, Lund
Opponent
- Matthias Friedrich