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The Importance of Magnesium in the Human Body: A Systematic Literature review

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Author

Editor

  • Gregory S. Makowski

Summary, in English

Magnesium, the second and fourth most abundant cation in the intracellular compartment and whole body, respectively, is of great physiologic importance. Magnesium exists as bound and free ionized forms depending on temperature, pH, ionic strength, and competing ions. Free magnesium participates in many biochemical processes and is most commonly measured by ion-selective electrode. This analytical approach is problematic because complete selectivity is not possible due to competition with other ions, i.e., calcium, and pH interference. Unfortunately, many studies have focused on measurement of total magnesium rather than its free bioactive form making it difficult to correlate to disease states. This systematic literature review presents current analytical challenges in obtaining accurate and reproducible test results for magnesium. © 2016 Elsevier Inc.

Publishing year

2016

Language

English

Pages

169-193

Publication/Series

Advances in Clinical Chemistry

Volume

73

Document type

Book chapter

Publisher

Academic Press

Topic

  • Inorganic Chemistry

Keywords

  • magmesium
  • human body
  • measurement

Status

Published

ISBN/ISSN/Other

  • ISSN: 0065-2423
  • ISBN: 978-0-12-804690-6