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Conserved function of the Krüppel gap gene in the blowfly Lucilia sericata, despite anterior shift of expression.

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Author

Summary, in English

To determine whether expression patterns of segmentation genes found in Drosophila melanogaster can be scaled to pattern larger insects, we studied the expression of the Krüppel (Kr) gene in the blowfly Lucilia sericata. Compared with Drosophila Kr, L. sericata Kr showed an unexpected 10% shift of expression towards the anterior pole. Furthermore, expression domains not found in D. melanogaster were present at the blastoderm stage of L. sericata. To compare Kr activity and function, we employed RNA interference-mediated gene silencing. We found Kr phenotypes in L. sericata comparable with those observed in D. melanogaster, demonstrating that L. sericata Kr functions as a gap gene as it does in Drosophila. Our results show that, despite an anterior shift in expression, Kr function has remained conserved during the evolution of the blowflies.

Department/s

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

Publishing year

2011

Language

English

Pages

257-265

Publication/Series

Insect Molecular Biology

Volume

20

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Developmental Biology

Status

Published

Project

  • Formation of the bicoid gradient in Drosophila

Research group

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

ISBN/ISSN/Other

  • ISSN: 1365-2583