The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

Summary, in English

The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.

• Author: Christer Nilsson; Päivi Kannisto; Maria Lindvall-Axelsson; Christer Owman; Evald Rosengren
• Department/s: Psychiatry (Lund); Obstetrics and Gynaecology (Lund); Drug Target Discovery; Department of Experimental Medical Science
• Publishing year: 1990
• Language: English
• Pages: 247-252
• Publication/Series: European Journal of Pharmacology
• Volume: 181
• Issue: 3
• Links: http://dx.doi.org/10.1016/0014-2999(90)90085-K
• Document type: Journal article
• Publisher: Elsevier
• Topic: Pharmacology and Toxicology
• Keywords: Presynaptic regulation; Sympathetic nerves; Choroid plexus; VIP (vasoactive intestinal polypeptide); PHI (peptide histidine isoleucine); Neuropeptide Y
• Status: Published
• Research group: Drug Target Discovery
• ISBN/ISSN/Other: ISSN: 1879-0712