The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Bioartificial nerve grafts based on absorbable guiding filament structures--early observations

På svenska

Author

Summary, in English

Gaps 10 mm wide in the sciatic nerves of 64 rats were bridged by bioartificial nerve grafts consisting of a silicone tube containing seven longitudinally placed filaments made of non-absorbable, (polyamide [Ethilon]) or absorbable, material (polydioxanone [PDS], polyglactin [Vicryl], and catgut). The purpose was to study the organisation of axonal growth inside the tube along such filaments. After two and four weeks histological techniques were used to study the contents of the tube and at four weeks immunohistological techniques were used to confirm the presence of axons distal to the tube. In all experimental groups axons had traversed the tube and reached the distal segment after four weeks. Inside the tube axons were organised in multiple minifascicles in all groups, but there were no axons growing in direct contact with the filaments. We conclude that resorbable filaments placed inside a silicone tube do not disturb axonal growth across the tube.

Publishing year

1997

Language

English

Pages

1-6

Publication/Series

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery

Volume

31

Issue

1

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Medical Biotechnology

Keywords

  • nerve regeneration
  • axonal growth
  • nerve graft
  • silicone chamber
  • resorbable filament
  • biomaterial

Status

Published

Research group

  • Hand Surgery, Malmö

ISBN/ISSN/Other

  • ISSN: 1651-2073