The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome

På svenska

Author

Summary, in English

Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.

Publishing year

1999

Language

English

Pages

857-860

Publication/Series

Thrombosis and Haemostasis

Volume

81

Issue

6

Document type

Journal article

Publisher

Schattauer GmbH

Topic

  • Cardiac and Cardiovascular Systems

Keywords

  • Activated Protein C Resistance
  • Acute Disease
  • Aged
  • Alleles
  • Coronary Disease
  • Factor V
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Polymorphism, Genetic
  • Prevalence
  • Prognosis
  • Risk Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

Research group

  • Clinical Chemistry, Malmö
  • Internal Medicine - Epidemiology
  • Clinical Coagulation, Malmö

ISBN/ISSN/Other

  • ISSN: 0340-6245