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Construction of a Pre-Clinical High Resolution Tomographic Scintillation Camera System

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Author

Summary, in English

We are constructing a High Resolution Tomographic Scintillation Camera System for small animal imaging. The system consists of a CsI(Tl) scintillator coupled to a military surplus image intensifier with a CCD camera focused on the output window. The system operates in photons counting mode and the spatial resolution is improved by centroid calculations for every photon interaction. The system can be mounted on an optical rail together with a pinhole collimator and a rotating table. A hot rod phantom was filled with Tl-201 or Tc-99m solute and imaged. The phantom rod diameters range from 1.1 to 1.6 mm. 64 projections were acquired (300 s/projection) with 1 mm pinhole insert. Data was reconstructed using an OSEM algorithm. Image data was corrected for decay, position non-linearities in image intensifier and the angular dependence of the pinhole. The reconstructed resolution is 13 mm (by visual inspection) for both Tc-99m and Tl-201. Higher spatial resolution is achievable with smaller pinhole diameters. Future work includes optimizing spatial resolution and sensitivity of a single system using analytical calculations, experiments and simulations. With the conclusions drawn from those calculations we plan to construct a multi-camera system.

Publishing year

2009

Language

English

Pages

3670-3671

Publication/Series

2009 IEEE Nuclear Science Symposium Conference Record, Vols 1-5

Document type

Conference paper

Publisher

IEEE - Institute of Electrical and Electronics Engineers Inc.

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • single photon imaging
  • component
  • small animal SPECT
  • molecular imaging

Conference name

IEEE Nuclear Science Symposium Conference 2009

Conference date

2009-10-25 - 2009-10-31

Status

Published

ISBN/ISSN/Other

  • ISSN: 1082-3654