High-fat diet impairs hippocampal neurogenesis in male rats.
Author
Summary, in English
High fat diets and obesity pose serious health problems, such as type II diabetes and cardiovascular disease. Impaired cognitive function is also associated with high fat intake. In this study, we show that just 4 weeks of feeding a diet rich in fat ad libitum decreased hippocampal neurogenesis in male, but not female, rats. There was no obesity, but male rats fed a diet rich in fat exhibited elevated serum corticosterone levels compared with those fed standard rat chow. These data indicate that high dietary fat intake can disrupt hippocampal neurogenesis, probably through an increase in serum corticosterone levels, and that males are more susceptible than females.
Department/s
- Neuroendocrine Cell Biology
- Wallenberg Neuroscience Centre, Lund
- Department of Experimental Medical Science
- Appetite Regulation
Publishing year
2006
Language
English
Pages
1385-1388
Publication/Series
European Journal of Neurology
Volume
13
Issue
12
Full text
- Available as PDF - 81 kB
- Download statistics
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Neurology
Keywords
- fat intake
- obesity
- memory
- hippocampus
- corticosterone
Status
Published
Research group
- Neuroendocrine Cell Biology
- Appetite Regulation
ISBN/ISSN/Other
- ISSN: 1351-5101