Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.
Author
Summary, in English
Increased production of reactive oxygen species (ROS) has been suggested as a cause of diabetic complications. Uncoupling proteins (UCPs) have been ascribed a role in reducing the formation of ROS, and genetic variation in genes encoding for UCPs could thus be putative candidate genes for diabetic nephropathy. To test this hypothesis we searched for association between the A→G (−3862) variant in UCP1, the insertion/deletion (I/D) polymorphism in exon 8 in UCP2, and the C→T (−55) polymorphism in UCP3 and diabetic nephropathy in 218 diabetic patients with normal urinary albumin excretion rate (AER), 216 with micro- or macroalbuminuria, and in 106 control subjects without a family history of diabetes. We did not find any association between the different polymorphisms and diabetic nephropathy, nor did we observe any difference in AER among carriers of different UCP1–3 genotypes. We could, however, confirm the reported association between BMI and the UCP3 −55 C→T polymorphism; patients carrying the T allele had higher BMI than patients homozygous for the C allele (26.4±4.2 vs. 25.3±4.3 kg/m2; P=.01). We conclude that studied polymorphisms in the UCP1–3 genes do not play a major role in the development of micro- or macroalbuminuria in Scandinavian diabetic patients.
Department/s
Publishing year
2004
Language
English
Pages
103-107
Publication/Series
Journal of Diabetes and its Complications
Volume
18
Issue
2
Full text
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Endocrinology and Diabetes
Keywords
- Uncoupling proteins
- Diabetes mellitus
- Microalbuminuria
- Polymorphisms
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
- Ophthalmology (Malmö)
ISBN/ISSN/Other
- ISSN: 1873-460X