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Cytogenetic abnormalities in a hemangiopericytoma of the spleen.

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Author

Summary, in English

To date, only 16 cytogenetically abnormal hemangiopericytomas (HP) have been reported. Despite this low number, some characteristic karyotypic features have already emerged: most HP are near-diploid and breakpoints in 12q13, 12q24, and 19q13 seem to be common, with t(12;19)(q13;q13) being a recurrent translocation. Here, we report the first case of a probably benign splenic HP with chromosomal abnormalities. The abnormal karyotype was 47,XX,t(5;22;11)(q31;q11;q13),+10. None of these abnormalities have previously been reported in HP, suggesting that the karyotypic pattern of splenic HP may differ from soft tissue HP.

Publishing year

2002

Language

English

Pages

62-65

Publication/Series

Cancer Genetics and Cytogenetics

Volume

136

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Surgery
  • Medical Genetics
  • Cancer and Oncology

Keywords

  • Male
  • Karyotyping
  • Immunohistochemistry
  • Human
  • Hemangiopericytoma : genetics
  • Female
  • Cytogenetic Analysis
  • Case Report
  • Chromosome Aberrations
  • Splenic Neoplasms : genetics

Status

Published

Research group

  • Surgery

ISBN/ISSN/Other

  • ISSN: 0165-4608