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Guiding molecular motors with nano-imprinted structures

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Author

Summary, in English

This work, for the first time, demonstrates that nano-imprinted samples, with 100 nm wide polymer lines, can act as guides for molecular motors consisting of motor proteins actin and myosin. The motor protein function was characterized using fluorescence microscopy and compared to actomyosin motility on non-structured nitrocellulose surfaces. Our results open for further use of the nano-imprint technique in the production of disposable chips for bio-nanotechnological applications and miniaturized biological test systems. We discuss how the nano-imprinted motor protein assay system may be optimized and also how it compares to previously tested assay systems involving low-resolution UV-lithography and low throughput but high-resolution electron beam lithography.

Publishing year

2005

Language

English

Pages

3337-3340

Publication/Series

Japanese Journal of Applied Physics

Volume

44

Issue

5A

Document type

Journal article

Publisher

IOP Publishing

Topic

  • Condensed Matter Physics

Keywords

  • lab-on-a-chip
  • myosin
  • actin
  • molecular motors
  • nano-imprinting
  • factory-on-a-chip

Status

Published

ISBN/ISSN/Other

  • ISSN: 0021-4922