Antioxidant metabolism induced by quinic acid. increased urinary excretion of tryptophan and nicotinamide.
Author
Summary, in English
For over 50 years, hippuric/quinic acids were believed to have no biological efficacy. Here data are presented to support the hypothesis that quinic acid is not responsible for any efficacy, but rather that quinic acid nutritionally supports the synthesis of tryptophan and nicotinamide in the gastrointestinal (GI) tract, and that this in turn leads to DNA repair enhancement and NF-kB inhibition via increased nicotinamide and tryptophan production.Moreover, it is shown that quinic acid is a normal constituent of our diet, capable of conversion to tryptophan and nicotinamide via the GI tract microflora, thus providing an in situ physiological source of these essential metabolic ingredients to humans. The concentrations of quinic and hippuric acids in the diet were dependent on each other when analysed in urine, as was evidenced by a significant linear regression analysis that included unsupplemented control subjects (n = 45, p < 0.001). Thus, these ingredients were identified as major dietary components, and not simply originating from environmental pollution as previously had been thought. Copyright (c) 2008 John Wiley & Sons, Ltd.
Department/s
- Immunology
Publishing year
2009
Language
English
Pages
335-346
Publication/Series
Phytotherapy Research
Volume
Oct 9
Links
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Pharmacology and Toxicology
Status
Published
Research group
- Immunology
ISBN/ISSN/Other
- ISSN: 1099-1573