Transcriptional profiling of breast cancer metastases identifies liver metastasis-selective genes associated with adverse outcome in luminal A primary breast cancer.

Summary, in English

The complete molecular basis of the organ-specificity of metastasis is elusive. This study aimed to provide an independent characterization of the transcriptional landscape of breast cancer metastases with the specific objective to identify liver metastasis-selective genes of prognostic importance following primary tumor diagnosis.

• Author: Siker Kimbung; Ida Johansson; Anna Danielsson; Srinivas Veerla; Suzanne Egyhazi Brage; Marianne Frostvik Stolt; Lambert Skoog; Lena Carlsson; Zakaria Einbeigi; Elisabet Lidbrink; Barbro Kristina Linderholm; Niklas Loman; Per Malmström; Martin Söderberg; Thomas M Walz; Mårten Fernö; Thomas Hatschek; Ingrid Hedenfalk
• Department/s: Breast and Ovarian Cancer Genomics; Breastcancer-genetics; Tumor microenvironment; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2016
• Language: English
• Pages: 146-157
• Publication/Series: Clinical Cancer Research
• Volume: 22
• Issue: 1
• Full text: - 2 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26276891?dopt=Abstract; http://dx.doi.org/10.1158/1078-0432.CCR-15-0487
• Document type: Journal article
• Publisher: American Association for Cancer Research
• Topic: Cancer and Oncology
• Status: Published
• Research group: Breast and Ovarian Cancer Genomics
• ISBN/ISSN/Other: ISSN: 1078-0432