Time course of striatal DeltaFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment.

Summary, in English

DFosB-like proteins are particularly stable transcription factors that accumulate in the brain in response to chronic perturbations. In this study we have compared the time-course of striatal FosB/DFosB-like immunoreactivity and prodynorphin mRNA expression after discontinuation of chronic cocaine treatment to intact rats and chronic L-DOPA treatment to unilaterally 6-hydroxydopamine (6-OHDA)

lesioned rats. The animals were killed between 3 h and 16 days after the last drug injection. In both treatment paradigms, the druginduced FosB/DFosB immunoreactivity remained significantly elevated in the caudate putamen even at the longest withdrawal period examined. The concomitant upregulation of prodynorphin mRNA, a target of DFosB, paralleled the time-course of DFosB-like immunoreactivity in the 6-OHDA-lesion/L-DOPA model, but was more transient in animals treated with cocaine. These results suggest that DFosB-like proteins have exceptional in vivo stability. In the dopamine-denervated striatum, these proteins may exert

sustained effects on the expression of their target genes long after discontinuation of L-DOPA pharmacotherapy.

• Author: M Andersson; J E Westin; Angela Cenci Nilsson
• Department/s: Neuronano Research Center (NRC); Basal Ganglia Pathophysiology
• Publishing year: 2003
• Language: English
• Pages: 661-666
• Publication/Series: European Journal of Neuroscience
• Volume: 17
• Issue: 3
• Full text: - 302 kB; Download statistics
• Links: http://dx.doi.org/10.1046/j.1460-9568.2003.02469.x
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Neurosciences
• Keywords: motor stereotypy; immediate-early genes; drugs of abuse; dyskinesia; Parkinson’s disease
• Status: Published
• Research group: Neuronano Research Center (NRC); Basal Ganglia Pathophysiology
• ISBN/ISSN/Other: ISSN: 1460-9568