TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
Author
Summary, in English
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.
Publishing year
2011
Language
English
Pages
272-274
Publication/Series
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume
35
Issue
2
Full text
Document type
Journal article
Publisher
Elsevier
Topic
- Cancer and Oncology
Keywords
- TP53 mutation
- 17p-deletion
- Prognosis
- Chronic lymphocytic leukemia
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-5835