The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Simulation and parametric study of a film-coated controlled-release pharmaceutical.

På svenska

Author

Summary, in English

Pharmaceutical formulations can be designed as Multiple Unit Systems, such as Roxiam CR, studied in this work. The dose is administrated as a capsule, which contains about 100 individual pellets, which in turn contain the active drug remoxipride. Experimental data for a large number of single pellets can be obtained by studying the release using microtitre plates. This makes it possible to study the release of the individual subunits making up the total dose. A mathematical model for simulating the release of remoxipride from single film-coated pellets is presented including internal and external mass transfer hindrance apart from the most important film resistance. The model can successfully simulate the release of remoxipride from single film-coated pellets if the lag phase of the experimental data is ignored. This was shown to have a minor influence on the release rate. The use of the present model is demonstrated by a parametric study showing that the release process is film-controlled, i.e. is limited by the mass transport through the polymer coating. The model was used to fit the film thickness and the drug loading to the experimental release data. The variation in the fitted values was similar to that obtained in the experiments.

Publishing year

2002

Language

English

Pages

229-245

Publication/Series

Journal of Controlled Release

Volume

80

Issue

1-3

Document type

Journal article

Publisher

Elsevier

Topic

  • Chemical Engineering

Keywords

  • Pharmaceutical Preparations : administration & dosage
  • Models
  • Chemical
  • Drug Implants : pharmacokinetics
  • Drug Implants : administration & dosage
  • Delayed-Action Preparations : pharmacokinetics
  • Computer Simulation
  • Delayed-Action Preparations : administration & dosage
  • Pharmaceutical Preparations : metabolism

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-4995